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    The First Affiliated Hospital of Zhongshan Medical University definitely has the technical strength, and there is no need for them to fly over.  The doctor who will be responsible for removing the donor's heart during the operation later will be Dr. Ye Chuanguang.

    "Do your doctors have any requirements for us?" Ye Chuanguang asked.

    While Xie Wanying was talking on the phone, she took out the ballpoint pen in her hand.

    Seeing this, classmate Wei helped her take out her notebook so that she could write in it.

    Xie Wanying wrote down the matters she wanted to coordinate with the other party for Teacher Cheng to review.

    Doctor Cheng Yuchen nodded while looking at it.

    After getting the teacher¡¯s consent, Xie Wanying said: ¡°First of all, the distance to transport the heart is relatively long and the journey takes a long time. Some preparations require your careful cooperation, Teacher Ye.¡±

    "You're welcome." Ye Chuanguang said frankly, "If you didn't call us, we would have wanted to ask you what your plans were. Do you need us to inject the donor heart from the aortic root and then inject cardioplegia to preserve it?"

    "Yes." A great teacher, he can understand it almost instantly without saying a word.

    "But you must be clear that the cold ischemia time of the heart should not exceed five or six hours." Ye Chuanguang kept reminding him, don't think that everything will be fine if you take more preparation steps, it will only prolong the time a little longer at most.

    Cold ischemia can be said to be a proper term in organ transplantation technology.  Before talking about cold ischemia, let¡¯s talk about another similar technical term: warm ischemia.

    The period of time before the organ is removed from the donor and placed in cold storage is called warm ischemia.  Cold ischemia corresponds to the time period from when the organ leaves the donor to when the organ is transplanted into the recipient. The most important thing here refers to the road transportation time.

    There are upper limits for warm ischemia and cold ischemia times for each organ.  For example, cardiac warm ischemia and cold ischemia have the shortest upper limits, which are ten minutes and eight hours respectively.  The ten minutes and eight hours here are super caps, equivalent to a big adventure.  No one can afford to take this risk easily.  Therefore, Dr. Ye said that the cold ischemia time should not exceed five or six hours.  Their hospital will control the warm ischemia time to within five minutes when removing a donor heart.

    What is going on when cardioplegia is injected?  Let¡¯s talk about it again. When the organ is removed from the donor, the cells are not dead and continue to metabolize.  Since the blood flow is interrupted and there is no blood nourishment, the organs taken out will inevitably undergo metabolic damage due to self-consumption.  It is conceivable that warm ischemia is the time period that causes the greatest damage to donor organs, and skilled professional doctors are needed to shorten the operation time as much as possible.

    How to protect the donor heart during the cold ischemia stage.  From a medical technical point of view, it is either the most ideal state to mechanically simulate a normal human body to continuously perfuse the donor heart, thus minimizing damage.  The problem is that long-distance transportation cannot do this at all, so we can only settle for the second best, using other methods to reduce the metabolism of the donor heart to reduce damage. Therefore, the general organ preservation solution must contain low temperature and other ingredients to inhibit organ cell metabolism.

    The energy consumption of the heart is mainly composed of the movement of cardiac contraction and relaxation and the metabolism of myocardial cells.  The former accounts for 90% of total consumption.  The use of cardioplegia can stop the mechanical activity of the heart, and low temperature reduces the metabolism of myocardial cells. The combination of the two is equal to one plus one, doubling the effect of reducing loss.

    Protecting the myocardium is one thing.

    On the other hand, because the heart is not like the liver and has a special structure, the donor heart and recipient need multiple anastomoses.

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